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トリガーポイントに関する文献

トリガーポイントの理解、治療に役立つ文献を幅広く集めて、リストしていきます。

*引用はハーバード方式に準じます。

邦文誌(五十音順)


阿部真博, 林功栄, 若月康次, 田口徹. (2017). ラット筋機械痛覚過敏に対するネオビタカイン®の鎮痛効果. ペインクリニック, 38(5), 645-654.
文献解説


伊藤和憲, 岡田薫, 川喜田健司. (2001). 伸張性収縮運動負荷によるトリガーポイントモデル作成の試み. 全日本鍼灸学会雑誌, 51(1), 81-90.


伊藤博志, 高山瑩, 岩間徹, 木下朋雄. (2001). 腰痛と下肢痛に対する神経ブロック療法とトリガーポイント注射の効果. 日本腰痛学会雑誌, 7(1), 110-113.


岩阪友俗. (1999). ネオビタカインの神経毒性に関する研究: 神経学的検査及び電子顕微鏡的検査から. ペインクリニック, 20(6), 869-875.
文献解説


亀山勉. (1980). Dibucaine hydrochloride, Sodium Salicylate と Calcium bromide の配合効果 (第1報) 鎮痛作用, 抗炎症作用ならびに急性毒性. 応用薬理, 20(4), 693-701.


唐沢克博, 石川初代, 安永幸弘, 今吉朋憲, 小松弘嗣. (2002). Dibucaine hydrochloride を主薬とする配合注射剤; Neo Vitacain®注の配合意義の検討 (第1報). 応用薬理, 63(1/2), 5-16.
文献解説


公文崇詞, 久保紳一郎, 黒木浩史. (2008). 臨床 腰痛症に対するジブカイン塩酸塩配合薬によるトリガーポイント注射の治療効果. 整形・災害外科, 51(1), 1477-1481.
文献解説


小山茂和. (2013). 膝内側関節裂隙痛に対するトリガーポイント注射の効果とその意義. 中部日本整形外科災害外科学会雑誌, 56(6), 1355-1356.
文献解説


佐々木健一. (1981). Dibucaine Hydrochloride, Sodium Salicylate と Calcium Bromide の配合効果 (第2報) 局所麻酔作用. 応用薬理, 21(3), 515-519.


佐々木朋宏, 山田徹. (2010). 緊張型頭痛患者に対するトリガーポイント注射による有用性の検討 新薬と臨床, 59(4) 178-183.


鈴木正寛, 堀夏樹, 春日高穂, 大瀬戸清茂. (2011). 進行がん患者の体性痛に対するトリガーポイント注射. 日本ペインクリニック学会誌, 18(2), 40-43.


高桑昌幸, 宮﨑東洋. (2011). 急性腰痛症におけるトリガーポイント注射による有用性の検討 ペインクリニック, 32(9), 1359-1368.


中山禎人, 表圭一, 川真田樹人, 並木昭義. (2003). 開胸術後の同側頸肩部疼痛に対するトリガーポイント注射の有用性. PAIN RESEARCH, 18(2), 67-70.


野口碩雄, 浅倉敏明, 岩岡勝義, 佐野幸寛, 下河辺建彦, 二田水節, 北城文男, 宮崎憲一郎, 宮崎正樹, 森田雅和. (2007). 肩関節周囲炎に対するネオビタカイン注のトリガーポイント注射の効果. Medical Postgraduates, 45(1), 42-46.
文献解説


橋爪圭司. (2000). ア・ラ・カルト/腰下肢のトリガーポイントブロック.鍼灸osaka, 16(4), 337-344.


林房次郎, 山下充, 田中敏彦, 村田望. (1998). Dibucaine hydrochloride を主剤とする配合注射剤 (Neo Vitacain®) の浸潤麻酔効果. 応用薬理, 55(1), 17-19.


堀田秀一. (2008).「ツボ注入」 の臨床効果 ネオビタカイン注を用いた不眠, 抑うつ, 肩こり, 頭痛の改善. Medical Postgraduates, 46(1), 35-40.


堀田秀一. (2010).「ツボ注入」の臨床効果 第2報―ネオビタカインを用いた腎虚の改善― 新薬と臨床, 59(7), 1237-1247.


宮崎東洋. (2010). がん患者の筋・筋膜性疼痛に対するトリガーポイント療法の有用性. ペインクリニック, 31(2), 195-203.


宮原桂子, 児玉謙次, 福元智子, 安田哲二郎. (2010). 筋・筋膜性肩甲背部痛および腰背部に対するネオビタカインと0.2%ロピバカインを用いたトリガーポイント注射の鎮痛効果 ペインクリニック, 31(7), 933-938.


森本昌宏. (1994). ペインクリニック疾患とその治療-16-局所浸潤注射法 (トリガ-・ポイント注射法) の実際. 東洋医学とペインクリニック, 24(2), p83-93.


森本昌宏. (2003). 筋 筋膜性疼痛の病態と治療: トリガーポイント注射による治療. ペインクリニック, 24(5), 789-794.
文献解説


森本昌宏. (2009). トリガーポイント注射 (日常診療に役立つ整形外科領域の痛みの知識)--(痛みの治療--神経ブロック療法の実際とコツ). 整形・災害外科, 52(5), 589-596.


森本昌宏. (2010). 肩こりの臨床--適切な診断と治療のために. 近畿大学医学雑誌, 35(3-4), 151-156.


森本昌宏, 白井達. (2014). トリガーポイント注射. 日本臨床麻酔学会誌, 34(7), 947-951.


森本昌宏, 松島麻由佳, 上原圭司. (2014). トリガーポイント注射. ペインクリニック, 35(6), 744-752.


山上裕章. (2000). ア・ラ・カルト/頸肩上肢痛に対するトリガーポイントブロック. 鍼灸osaka, 16(4), 355-362.


山口亜沙美, 荻野嘉丈, 岩腰千絵, 唐沢克博, 大木正彦. (2011). がん患者の筋・筋膜性疼痛に対するトリガーポイント療法の調査 (第一報)―ネオビタカイン® 注の特定使用成績調査の解析結果から―. 癌と化学療法, 38(10), 1659-1665.
文献解説


山口亜沙美, 荻野嘉丈, 岩腰千絵, 唐沢克博, 大木正彦. (2012). がん患者の筋・筋膜性疼痛に対するトリガーポイント療法の調査 (第二報)―ネオビタカイン® 注の特定使用成績調査の分析結果から―. 癌と化学療法, 39(4), 605-611.


吉村文貴. (2016). トリガーポイント注射における局所麻酔製剤の注入時痛の検討-ジブカイン配合薬(ネオビタカイン®注)とメピバカイン注射薬(カルボカイン®注)の比較-ペインクリニック, 37(7), 957-959.


吉村文貴. (2020). 僧帽筋へのトリガーポイント注射における注入部位の検討. ペインクリニック学会誌, 27(2), 17-22.

欧文誌(アルファベット順)


Aghababian, R. V., Volturo, G. A., & Heifetz, I. N. (1986). Comparison of diflunisal and naproxen in the management of acute low back strain. Clinical therapeutics, 9, 47-51.


Alonso-Blanco, C., Fernández-de-Las-Peñas, C., de-la-Llave-Rincón, A. I., Zarco-Moreno, P., Galán-del-Río, F., & Svensson, P. (2012). Characteristics of referred muscle pain to the head from active trigger points in women with myofascial temporomandibular pain and fibromyalgia syndrome. The journal of headache and pain, 13(8), 625-637.


Alvarez, D. J., & Rockwell, P. G. (2002). Trigger points: diagnosis and management. American family physician, 65(4), 653-662.


Amann, R., & Peskar, B. A. (2002). Anti-inflammatory effects of aspirin and sodium salicylate. European journal of pharmacology, 447(1), 1-9.


Arendt-Nielsen, L., Nie, H., Laursen, M. B., Laursen, B. S., Madeleine, P., Simonsen, O. H., & Graven-Nielsen, T. (2010). Sensitization in patients with painful knee osteoarthritis. Pain, 149(3), 573-581.


Aromataris, E. C., & Rychkov, G. Y. (2006). ClC‐1 CHLORIDE CHANNEL: MATCHING ITS PROPERTIES TO A ROLE IN SKELETAL MUSCLE. Clinical and experimental pharmacology and physiology, 33(11), 1118-1123.


Ashkenazi, A., Blumenfeld, A., Napchan, U., Narouze, S., Grosberg, B., Nett, R., & Lipton, R. B. (2010). Peripheral nerve blocks and trigger point injections in headache management–a systematic review and suggestions for future research. Headache: The Journal of Head and Face Pain, 50(6), 943-952.


Baibergenova, A., & Murray, C. A. (2011). Techniques to minimize the pain of injected local anesthetic. Journal of cutaneous medicine and surgery, 15(5), 250-253.


Baldry, P. (2002). Management of myofascial trigger point pain. Acupuncture in medicine, 20(1), 2-10.


Baron, A., Deval, E., Salinas, M., Lingueglia, E., Voilley, N., & Lazdunski, M. (2002). Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1. Journal of Biological Chemistry, 277(52), 50463-50468.


Baron, A., Voilley, N., Lazdunski, M., & Lingueglia, E. (2008). Acid sensing ion channels in dorsal spinal cord neurons. Journal of Neuroscience, 28(6), 1498-1508.


Baron, A., & Lingueglia, E. (2015). Pharmacology of acid-sensing ion channels–Physiological and therapeutical perspectives. Neuropharmacology, 94, 19-35.


Becker, D. E., & Reed, K. L. (2006). Essentials of local anesthetic pharmacology. Anesthesia progress, 53(3), 98-109.


Bedaiwy, M. A., Patterson, B., & Mahajan, S. (2013). Prevalence of myofascial chronic pelvic pain and the effectiveness of pelvic floor physical therapy. The Journal of reproductive medicine, 58(11-12), 504-510.


Bendtsen, L., & Jensen, R. (2006). Tension-type headache: the most common, but also the most neglected, headache disorder. Current opinion in neurology, 19(3), 305-309.


Bennett, R. (2007). Myofascial pain syndromes and their evaluation. Best practice & research Clinical rheumatology, 21(3), 427-445.


Blikstad, A., & Gemmell, H. (2008). Immediate effect of activator trigger point therapy and myofascial band therapy on non-specific neck pain in patients with upper trapezius trigger points compared to sham ultrasound: a randomised controlled trial. Clinical Chiropractic, 11(1), 23-29.


Bogduk, N. (2004). Management of chronic low back pain. Medical journal of Australia, 180(2), 79.


Boix, F., Rosenborg, L., Hilgenfeldt, U., & Knardahl, S. (2002). Contraction‐related factors affect the concentration of a kallidin‐like peptide in rat muscle tissue. The Journal of physiology, 544(1), 127-136.


Borg-Stein, J., & Simons, D. G. (2002). Myofascial pain. Archives of physical medicine and rehabilitation, 83, S40-S47.


Boswell, M. V., Trescot, A. M., Datta, S., Schultz, D. M., Hansen, H. C., Abdi, S., & Patel, V. B. (2007). Interventional techniques: evidence-based practice guidelines in the management of chronic spinal pain. Pain physician, 10(1), 7-111.


Botwin, K. P., & Patel, B. C. (2007). Electromyographically guided trigger point injections in the cervicothoracic musculature of obese patients: a new and unreported technique. Pain Physician, 10(6), 753.


Brioschi, M., Argawal, K., & Zhang Ho, S. R. (2010). International Consensus and Guidelines on Medical Thermology in Fortaleza. Brazil, October, 127-142.


Bron, C., De Gast, A., Dommerholt, J., Stegenga, B., Wensing, M., & Oostendorp, R. A. (2011). Treatment of myofascial trigger points in patients with chronic shoulder pain: a randomized, controlled trial. BMC medicine, 9(1), 8.


Bron, C., & Dommerholt, J. D. (2012). Etiology of myofascial trigger points. Current pain and headache reports, 16(5), 439-444.


Burns, C. A., Ferris, G., Feng, C., Cooper, J. Z., & Brown, M. D. (2006). Decreasing the pain of local anesthesia: a prospective, double-blind comparison of buffered, premixed 1% lidocaine with epinephrine versus 1% lidocaine freshly mixed with epinephrine. Journal of the American Academy of Dermatology, 54(1), 128-131.


Cardoso, L. R., Rizzo, C. C., de Oliveira, C. Z., dos Santos, C. R., & Carvalho, A. L. (2015). Myofascial pain syndrome after head and neck cancer treatment: prevalence, risk factors, and influence on quality of life. Head & neck, 37(12), 1733-1737.


Carlson, C. R., Okeson, J. P., Falace, D. A., Nitz, A. J., & Lindroth, J. E. (1993). Reduction of pain and EMG activity in the masseter region by trapezius trigger point injection. Pain, 55(3), 397-400.


Castrinoti, E. E., Ernberg, M., Cairns, B. E., Wang, K., Sessle, B. J., Arendt-Nielsen, L., & Svensson, P. (2010). Interstitial glutamate concentration is elevated in the masseter muscle of myofascial temporomandibular disorder patients. Journal of orofacial pain, 24(4).


Cakit, B. D., Taskin, S., Nacir, B., Unlu, I., Genc, H., & Erdem, H. R. (2010). Comorbidity of fibromyalgia and cervical myofascial pain syndrome. Clinical rheumatology, 29(4), 405-411.


Celik, D., & Mutlu, E. K. (2013). Clinical implication of latent myofascial trigger point. Current pain and headache reports, 17(8), 353.


Chandola, H. C., & Chakraborty, A. (2009). Fibromyalgia and myofascial pain syndrome-a dilemma. Indian journal of anaesthesia, 53(5), 575.


Chen, C. K., & Nizar, A. J. (2011). Myofascial pain syndrome in chronic back pain patients. The Korean journal of pain, 24(2), 100-104.


Chen, C. C., & Wong, C. W. (2013). Neurosensory mechanotransduction through acid‐sensing ion channels. Journal of cellular and molecular medicine, 17(3), 337-349.


Chen, Q., Bensamoun, S., Basford, J. R., Thompson, J. M., & An, K. N. (2007). Identification and quantification of myofascial taut bands with magnetic resonance elastography. Archives of physical medicine and rehabilitation, 88(12), 1658-1661.


Chen, Q., Basford, J., & An, K. N. (2008). Ability of magnetic resonance elastography to assess taut bands. Clinical Biomechanics, 23(5), 623-629.


Chen, W. K., Liu, I. Y., Chang, Y. T., Chen, Y. C., Chen, C. C., Yen, C. T., & Chen, C. C. (2010). Cav3. 2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain. Journal of Neuroscience, 30(31), 10360-10368.


Chen, Y., Song, B. O., Jin, X. Y., Xiong, E. Q., & Zhang, J. H. (2005). Possible mechanism of referred pain in the perineum and pelvis associated with the prostate in rats. The Journal of urology, 174(6), 2405-2408.


Cheng, J., & Abdi, S. (2007). Complications of joint, tendon, and muscle injections. Techniques in Regional Anesthesia and Pain Management, 11(3), 141-147.


Cheshire, W. P., Abashian, S. W., & Mann, J. D. (1994). Botulinum toxin in the treatment of myofascial pain syndrome. Pain, 59(1), 65-69.


Cheung, K. M., Samartzis, D., Karppinen, J., & Luk, K. D. (2012). Are “patterns” of lumbar disc degeneration associated with low back pain?: new insights based on skipped level disc pathology. Spine, 37(7), E430-E438.


Chiarotto, A., Clijsen, R., Fernandez-de-las-Penas, C., & Barbero, M. (2016). Prevalence of myofascial trigger points in spinal disorders: a systematic review and meta-analysis. Archives of physical medicine and rehabilitation, 97(2), 316-337.


Choi, J. I. (2014). Chicken and egg: peripheral nerve entrapment or myofascial trigger point?. The Korean journal of pain, 27(2), 186-188.



Chung, J. W., Ohrbach, R., & McCall Jr, W. D. (2004). Effect of increased sympathetic activity on electrical activity from myofascial painful areas. American journal of physical medicine & rehabilitation, 83(11), 842-850.


Chou, R., Qaseem, A., Snow, V., Casey, D., Cross, J. T., Shekelle, P., & Owens, D. K. (2007). Diagnosis and Treatment of Low Back Pain: A Joint Clinical Practice Guideline from the American College of Physicians and the American Pain SocietyDiagnosis and Treatment of Low Back Pain. Annals of internal medicine, 147(7), 478-491.


Chou, R., Qaseem, A., Owens, D. K., & Shekelle, P. (2011). Diagnostic imaging for low back pain: advice for high-value health care from the American College of Physicians. Annals of internal medicine, 154(3), 181-189.


Clemente, M. P., Coimbra, D., Silva, A., Grabriel, J., & Pinho, J. (2011). Can infrared thermography be a diagnostic tool for myofascial pain in wind and string instrument players. Proc. of the ISPS. Utrecht:(AEC).


Cojocaru, M. C., Cojocaru, I. M., Voiculescu, V. M., Cojan-Carlea, N. A., Dumitru, V. L., & Berteanu, M. (2015). Trigger points–ultrasound and thermal findings. Journal of medicine and life, 8(3), 315.


Conklin, K. A. (1987). Pharmacology of local anesthetics. AANA journal, 55(1), 36-44.


Crossman, K., Mahon, M., Watson, P. J., Oldham, J. A., & Cooper, R. G. (2004). Chronic low back pain-associated paraspinal muscle dysfunction is not the result of a constitutionally determined “adverse” fiber-type composition. Spine, 29(6), 628-634.


de Abreu Venâncio, R., Guedes Pereira Alencar, F., & Zamperini, C. (2008). Different substances and dry-needling injections in patients with myofascial pain and headaches. CRANIO®, 26(2), 96-103.


de Abreu Venancio, R., Guedes Pereira Alencar, F., & Zamperini, C. (2009). Botulinum toxin, lidocaine, and dry-needling injections in patients with myofascial pain and headaches. CRANIO®, 27(1), 46-53.


Deval, E., Gasull, X., Noël, J., Salinas, M., Baron, A., Diochot, S., & Lingueglia, E. (2010). Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacology & therapeutics, 128(3), 549-558.


Devor, M. (1991). Neuropathic pain and injured nerve: peripheral mechanisms. British Medical Bulletin, 47(3), 619-630.


Dadabhoy, D., Crofford, L. J., Spaeth, M., Russell, I. J., & Clauw, D. J. (2008). Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome. Arthritis research & therapy, 10(4), 211.


Dalpiaz, A. S., Lordon, S. P., & Lipman, A. G. (2004). Topical lidocaine patch therapy for myofascial pain. Journal of pain & palliative care pharmacotherapy, 18(3), 15-34.


Desai, M. J., Saini, V., & Saini, S. (2013). Myofascial pain syndrome: A treatment review. Pain and therapy, 2(1), 21-36.


DeSantana, J. M., & Sluka, K. A. (2008). Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain. Current pain and headache reports, 12(5), 338-343.


Deval, E., Gasull, X., Noël, J., Salinas, M., Baron, A., Diochot, S., & Lingueglia, E. (2010). Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacology & therapeutics, 128(3), 549-558.


Deval, E., Noël, J., Gasull, X., Delaunay, A., Alloui, A., Friend, V., & Lingueglia, E. (2011). Acid-sensing ion channels in postoperative pain. Journal of Neuroscience, 31(16), 6059-6066.


Deval, E., & Lingueglia, E. (2015). Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems. Neuropharmacology, 94, 49-57.


Domingo, T., Blasi, J., Casals, M., Mayoral, V., Ortiz-Sagristá, J. C., & Miguel-Pérez, M. (2011). Is interfascial block with ultrasound-guided puncture useful in treatment of myofascial pain of the trapezius muscle?. The Clinical journal of pain, 27(4), 297-303.


Dommerholt, J., Bron, C., & Franssen, J. (2006). Myofascial trigger points: an evidence-informed review. Journal of Manual & Manipulative Therapy, 14(4), 203-221.


Dommerholt, J., Mayoral del Moral, O., & Gröbli, C. (2006). Trigger point dry needling. Journal of Manual & Manipulative Therapy, 14(4), 70E-87E.


Doraisamy, M. A., & Gnanamuthu, C. (2010). Chronic tension type headache and the impact of myofascial trigger point release in the short term relief of headache. Global Journal of Health Science, 2(2), 238.


Dorsher, P. T. (2009). Myofascial referred-pain data provide physiologic evidence of acupuncture meridians. The Journal of Pain, 10(7), 723-731.


Dworkin, R. H., Backonja, M., Rowbotham, M. C., Allen, R. R., Argoff, C. R., Bennett, G. J., & Hewitt, D. J. (2003). Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Archives of neurology, 60(11), 1524-1534.


Eisenhut, M., & Wallace, H. (2011). Ion channels in inflammation. Pflügers Archiv-European Journal of Physiology, 461(4), 401-421.


Eltzschig, H. K., & Carmeliet, P. (2011). Hypoxia and inflammation. New England Journal of Medicine, 364(7), 656-665.


Ernberg, M., Hedenberg-Magnusson, B., Alstergren, P., & Kopp, S. (1999). The level of serotonin in the superficial masseter muscle in relation to local pain and allodynia. Life sciences, 65(3), 313-325.


Ernberg, M., Lundeberg, T., & Kopp, S. (2000). Pain and allodynia/hyperalgesia induced by intramuscular injection of serotonin in patients with fibromyalgia and healthy individuals. Pain, 85(1), 31-39.


Farasyn, A. (2007). Referred muscle pain is primarily peripheral in origin: the “barrier-dam” theory. Medical hypotheses, 68(1), 144-150.


Fernández‐de‐las‐Peñas, C., Cuadrado, M. L., Arendt‐Nielsen, L., Simons, D. G., & Pareja, J. A. (2007). Myofascial trigger points and sensitization: an updated pain model for tension‐type headache. Cephalalgia, 27(5), 383-393.


Fernández‐de‐las‐Peñas, C., Cuadrado, M. L., Gerwin, R. D., & Pareja, J. A. (2009). Referred Pain Elicited by Manual Exploration of the Lateral Rectus Muscle in Chronic Tension‐Type Headache. Pain Medicine, 10(1), 43-48.


Fernández-de-las-Peñas, C., & Dommerholt, J. (2014). Myofascial trigger points: peripheral or central phenomenon?. Current rheumatology reports, 16(1), 395.
文献解説


Ferrante, F. M., Bearn, L., Rothrock, R., & King, L. (2005). Evidence against trigger point injection technique for the treatment of cervicothoracic myofascial pain with botulinum toxin type A. The Journal of the American Society of Anesthesiologists, 103(2), 377-383.


Fine, P. G., Milano, R., & Hare, B. D. (1988). The effects of myofascial trigger point injections are naloxone reversible. Pain, 32(1), 15-20.


Finnerup, N. B., Otto, M., McQuay, H. J., Jensen, T. S., & Sindrup, S. H. (2005). Algorithm for neuropathic pain treatment: an evidence based proposal. Pain, 118(3), 289-305.


Firmani, M., Miralles, R., & Casassus, R. (2015). Effect of lidocaine patches on upper trapezius EMG activity and pain intensity in patients with myofascial trigger points: A randomized clinical study. Acta Odontologica Scandinavica, 73(3), 210-218.


Fleckenstein, J., Zaps, D., Rüger, L. J., Lehmeyer, L., Freiberg, F., Lang, P. M., & Irnich, D. (2010). Discrepancy between prevalence and perceived effectiveness of treatment methods in myofascial pain syndrome: results of a cross-sectional, nationwide survey. BMC musculoskeletal disorders, 11(1), 32.


Flodgren, G. M., Crenshaw, A. G., Alfredson, H., Fahlström, M., Hellström, F. B., Bronemo, L., & Djupsjöbacka, M. (2005). Glutamate and prostaglandin E2 in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis. European journal of pain, 9(5), 511-511.


Freeman, M. D., Nystrom, A., & Centeno, C. (2009). Chronic whiplash and central sensitization; an evaluation of the role of a myofascial trigger points in pain modulation. Journal of brachial plexus and peripheral nerve injury, 4(1), 2.


Frost, F. A., Jessen, B., & Siggaard-Andersen, J. (1980). A control, double-blind comparison of mepivacaine injection versus saline injection for myofascial pain. The Lancet, 315(8167), 499-501.


Frost, A. (1986). Diclofenac versus lidocaine as injection therapy in myofascial pain. Scandinavian journal of rheumatology, 15(2), 153-156.


Fujii, Y., Ozaki, N., Taguchi, T., Mizumura, K., Furukawa, K., & Sugiura, Y. (2008). TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness. Pain, 140(2), 292-304.


Ga, H., Koh, H. J., Choi, J. H., & Kim, C. H. (2007). Intramuscular and nerve root stimulation vs lidocaine injection of trigger points in myofascial pain syndrome. Journal of Rehabilitation medicine, 39(5), 374-378.


Ga, H., Choi, J. H., Park, C. H., & Yoon, H. J. (2007). Acupuncture needling versus lidocaine injection of trigger points in myofascial pain syndrome in elderly patients–a randomised trial. Acupuncture in Medicine, 25(4), 130-136.


Garvey, T. A., Marks, M. R., & Wiesel, S. W. (1989). A prospective, randomized, double-blind evaluation of trigger-point injection therapy for low-back pain. Spine, 14(9), 962-964.


Ge, H. Y., Fernández-de-las-Peñas, C., & Arendt-Nielsen, L. (2006). Sympathetic facilitation of hyperalgesia evoked from myofascial tender and trigger points in patients with unilateral shoulder pain. Clinical neurophysiology, 117(7), 1545-1550.


Ge, H. Y., Nie, H., Madeleine, P., Danneskiold-Samsøe, B., Graven-Nielsen, T., & Arendt-Nielsen, L. (2009). Contribution of the local and referred pain from active myofascial trigger points in fibromyalgia syndrome. PAIN®, 147(1), 233-240.


Ge, H. Y., Fernández-de-las-Peñas, C., & Yue, S. W. (2011). Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation. Chinese medicine, 6(1), 13.


Ge, H. Y., Wang, Y., Fernández-de-las-Peñas, C., Graven-Nielsen, T., Danneskiold-Samsøe, B., & Arendt-Nielsen, L. (2011). Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients. Arthritis research & therapy, 13(2), R48.


Gerber, R. K. H., Nie, H., Arendt-Nielsen, L., Curatolo, M., & Graven-Nielsen, T. (2011). Local pain and spreading hyperalgesia induced by intramuscular injection of nerve growth factor are not reduced by local anesthesia of the muscle. The Clinical journal of pain, 27(3), 240-247.


Gerdle, B., Söderberg, K., Puigvert, L. S., Rosendal, L., & Larsson, B. (2010). Increased interstitial concentrations of pyruvate and lactate in the trapezius muscle of patients with fibromyalgia: a microdialysis study. Journal of rehabilitation medicine, 42(7), 679-687.


Gerdle, B., Ghafouri, B., Ernberg, M., & Larsson, B. (2014). Chronic musculoskeletal pain: review of mechanisms and biochemical biomarkers as assessed by the microdialysis technique. Journal of pain research, 7, 313.


Gerwin, R. D. (2001). Classification, epidemiology, and natural history of myofascial pain syndrome. Current pain and headache reports, 5(5), 412-420.


Gerwin, R. D., Dommerholt, J., & Shah, J. P. (2004). An expansion of Simons’ integrated hypothesis of trigger point formation. Current pain and headache reports, 8(6), 468-475.


Gerwin, R. D. (2005). A review of myofascial pain and fibromyalgia–factors that promote their persistence. Acupuncture in Medicine, 23(3), 121-134.


Gerwin, R. D., Dommerholt, J., & Shah, J. P. (2004). An expansion of Simons’ integrated hypothesis of trigger point formation. Current pain and headache reports, 8(6), 468-475.


Giamberardino, M. A., Affaitati, G., Fabrizio, A., & Costantini, R. (2011). Myofascial pain syndromes and their evaluation. Best practice & research Clinical rheumatology, 25(2), 185-198.


Giamberardino, M. A., Affaitati, G., Fabrizio, A., & Costantini, R. (2011). Effects of treatment of myofascial trigger points on the pain of fibromyalgia. Current pain and headache reports, 15(5), 393.


Graboski, C. L., Gray, D. S., & Burnham, R. S. (2005). Botulinum toxin A versus bupivacaine trigger point injections for the treatment of myofascial pain syndrome: a randomised double blind crossover study. Pain, 118(1), 170-175.


Graven-Nielsen, T., & Arendt-Nielsen, L. (2010). Assessment of mechanisms in localized and widespread musculoskeletal pain. Nature Reviews Rheumatology, 6(10), 599-606.


Guan, L., Shi, X., Zou, Y., Deng, X. F., & Cai, P. S. (2010). Effect on body surface thermograph in patients with myofascial pain syndrome treated with moxibustion on Yanglingquan (GB 34). Zhongguo zhen jiu= Chinese acupuncture & moxibustion, 30(6), 485-489.


Gül, K., & Onal, S. A. (2009). Comparison of non-invasive and invasive techniques in the treatment of patients with myofascial pain syndrome. Agri: Agri (Algoloji) Dernegi'nin Yayin organidir= The journal of the Turkish Society of Algology, 21(3), 104-112.


Haddad, D. S., Brioschi, M. L., & Arita, E. S. (2012). Thermographic and clinical correlation of myofascial trigger points in the masticatory muscles. Dentomaxillofacial Radiology, 41(8), 621-629.


Hakgüder, A., Birtane, M., Gürcan, S., Kokino, S., & Nesrin Turan, F. (2003). Efficacy of low level laser therapy in myofascial pain syndrome: an algometric and thermographic evaluation. Lasers in surgery and medicine, 33(5), 339-343.


Hallman, D. M., & Lyskov, E. (2012). Autonomic regulation in musculoskeletal pain. In Pain in perspective. InTech.


Han, D. G. (2009). The other mechanism of muscular referred pain: The “connective tissue” theory. Medical hypotheses, 73(3), 292-295.


Handa, T., Fukuda, K. I., & Ichinohe, T. (2013). Effect of combination of trigger point injection and stellate ganglion block on non-odontogenic mandibular molar pain referred from masseter muscle: a case report. The Bulletin of Tokyo Dental College, 54(3), 171-175.


Hameroff, S. R., Crago, B. R., Blitt, C. D., Womble, J., Kanel, J. (1981). Comparison of bupivacaine, etidocaine, and saline for trigger-point therapy. Anesthesia and analgesia, 60(10), 752-755.


Harden, R. N., Cottrill, J., Gagnon, C. M., Smitherman, T. A., Weinland, S. R., Tann, B., ... & Houle, T. T. (2009). Botulinum Toxin A in the Treatment of Chronic Tension‐Type Headache With Cervical Myofascial Trigger Points: A Randomized, Double‐Blind, Placebo‐Controlled Pilot Study. Headache: The Journal of Head and Face Pain, 49(5), 732-743.


Hayashi, K., Ozaki, N., Kawakita, K., Itoh, K., Mizumura, K., Furukawa, K., ... & Sugiura, Y. (2011). Involvement of NGF in the rat model of persistent muscle pain associated with taut band. The Journal of Pain, 12(10), 1059-1068.


Hayashi, K., Katanosaka, K., Abe, M., Yamanaka, A., Nosaka, K., Mizumura, K., & Taguchi, T. (2017). Muscular mechanical hyperalgesia after lengthening contractions in rats depends on stretch velocity and range of motion. European Journal of Pain, 21(1), 125-139.


Hedenberg-Magnusson, B., Ernberg, M., Alstergren, P., & Kopp, S. (2001). Pain mediation by prostaglandin E2 and leukotriene B4 in the human masseter muscle. Acta odontologica Scandinavica, 59(6), 348-355.


Hedenberg-Magnusson, B., Ernberg, M., Alstergren, P., & Kopp, S. (2002). Effect on prostaglandin E2 and leukotriene B4 levels by local administration of glucocorticoid in human masseter muscle myalgia. Acta odontologica Scandinavica, 60(1), 29-36.


Hedenberg-Magnusson, B., Brodda Jansen, G., Ernberg, M., & Kopp, S. (2006). Effects of isometric contraction on intramuscular level of neuropeptide Y and local pain perception. Acta Odontologica Scandinavica, 64(6), 360-367.


Hides, J. A., Richardson, C. A., & Jull, G. A. (1996). Multifidus muscle recovery is not automatic after resolution of acute, first‐episode low back pain. Spine, 21(23), 2763-2769.


Hoheisell, U., Taguchil, T., Treedel, R. D., & Mensel, S. (2011). Nociceptive input from the rat thoracolumbar fascia to lumbar dorsal horn neurones. European Journal of Pain, 15(8), 810-815.


Hong, C. Z. (1994). LIDOCAINE INJECTION VERSUS DRY NEEDLING TO MYOFASCIAL TRIGGER POINT: The Importance of the Local Twitch Response. American journal of physical medicine & rehabilitation, 73(4), 256-263.


Hong, C. Z., & Hsueh, T. C. (1996). Difference in pain relief after trigger point injections in myofascial pain patients with and without fibromyalgia. Archives of physical medicine and rehabilitation, 77(11), 1161-1166.


Hong, C. Z., & Simons, D. G. (1998). Pathophysiologic and electrophysiologic mechanisms of myofascial trigger points. Archives of physical medicine and rehabilitation, 79(7), 863-872.


Hong, C. Z. (2000). Myofascial trigger points: pathophysiology and correlation with acupuncture points. Acupuncture in Medicine, 18(1), 41-47.


Hoy, D., Bain, C., Williams, G., March, L., Brooks, P., Blyth, F., & Buchbinder, R. (2012). A systematic review of the global prevalence of low back pain. Arthritis & Rheumatology, 64(6), 2028-2037.


Hsieh, Y. L., Kao, M. J., Kuan, T. S., Chen, S. M., Chen, J. T., & Hong, C. Z. (2007). Dry needling to a key myofascial trigger point may reduce the irritability of satellite MTrPs. American journal of physical medicine & rehabilitation, 86(5), 397-403.


Hsieh, L. F., Hong, C. Z., Chern, S. H., & Chen, C. C. (2010). Efficacy and side effects of diclofenac patch in treatment of patients with myofascial pain syndrome of the upper trapezius. Journal of pain and symptom management, 39(1), 116-125.


Hsieh, Y. L., Yang, S. A., Yang, C. C., & Chou, L. W. (2012). Dry needling at myofascial trigger spots of rabbit skeletal muscles modulates the biochemicals associated with pain, inflammation, and hypoxia. Evidence-based complementary and alternative medicine, 2012.


Hubbard, D. R. (1996). Chronic and recurrent muscle pain: pathophysiology and treatment, and review of pharmacologic studies. Journal of Musculoskeletal Pain, 4(1-2), 123-144.


Huguenin, L. K. (2004). Myofascial trigger points: the current evidence. Physical therapy in sport, 5(1), 2-12.


Huijbregts, P. A. (2006). Myofascial Trigger Points and Myofascial Pain Syndrome: A Critical Review of Recent Literature An Introduction by the editor-in-Chief. Journal of Manual & Manipulative Therapy, 14(4), 124E-124E.


Hyodo, H., Sato, T., Sasaki, H., & Tanaka, Y. (2005). Discogenic pain in acute nonspecific low-back pain. European Spine Journal, 14(6), 573-577.


Iguchi, M., Katoh, Y., Koike, H., Hayashi, T., & Nakamura, M. (2002). Randomized trial of trigger point injection for renal colic. International journal of urology, 9(9), 475-479.


Ikeda, H., Kiritoshi, T., & Murase, K. (2012). Contribution of microglia and astrocytes to the central sensitization, inflammatory and neuropathic pain in the juvenile rat. Molecular pain, 8(1), 43.


Immke, D. C., & McCleskey, E. W. (2003). Protons open acid-sensing ion channels by catalyzing relief of Ca 2+ blockade. Neuron, 37(1), 75-84.


Itoh, K., & Kawakita, K. (2002). Effect of indomethacin on the development of eccentric exercise-induced localized sensitive region in the fascia of the rabbit. The Japanese journal of physiology, 52(2), 173-180.


Itoh, K., Okada, K., & Kawakita, K. (2004). A proposed experimental model of myofascial trigger points in human muscle after slow eccentric exercise. Acupuncture in medicine, 22(1), 2-2.


Itoh, K., Saito, S., Sahara, S., Naitoh, Y., Imai, K., & Kitakoji, H. (2014). Randomized trial of trigger point acupuncture treatment for chronic shoulder pain: a preliminary study. Journal of acupuncture and meridian studies, 7(2), 59-64.


Itza, F., Zarza, D., Salinas, J., Teba, F., & Ximenez, C. (2015). turn-amplitude analysis as a diagnostic test for myofascial syndrome in patients with chronic pelvic pain. Pain Research and Management, 20(2), 96-100.


Iwama, H., Ohmori, S., Kaneko, T., & Watanabe, K. (2001). Water-diluted local anesthetic for trigger-point injection in chronic myofascial pain syndrome: evaluation of types of local anesthetic and concentrations in water. Regional anesthesia and pain medicine, 26(4), 333-336.


Jafri, M. S. (2014). Mechanisms of myofascial pain. International scholarly research notices, 2014, Article ID 523924, 16 pages.


Jensen, S. (2004). Back pain-clinical assessment. Australian family physician, 33(6), 393.


Jermyn, R. T. (2001). A nonsurgical approach to low back pain. The Journal of the American Osteopathic Association, 101(4_suppl_2), 6S-11S.


Jørgensen, K. (1997). Human trunk extensor muscles physiology and ergonomics. Acta Physiologica Scandinavica. Supplementum, 637, 1-58.


Kader, D. F., Wardlaw, D., & Smith, F. W. (2000). Correlation between the MRI changes in the lumbar multifidus muscles and leg pain. Clinical radiology, 55(2), 145-149.


Kamanli, A., Kaya, A., Ardicoglu, O., Ozgocmen, S., Zengin, F. O., & Bayık, Y. (2005). Comparison of lidocaine injection, botulinum toxin injection, and dry needling to trigger points in myofascial pain syndrome. Rheumatology international, 25(8), 604-611.


Kannan, P. (2012). Management of myofascial pain of upper trapezius: a three group comparison study. Global journal of health science, 4(5), 46.


Karadas, Ö., Gül, H. L., & İnan, L. E. (2013). Lidocaine injection of pericranial myofascial trigger points in the treatment of frequent episodic tension-type headache. The journal of headache and pain, 14(1), 44, 8 pages


Käser, L., Mannion, A. F., Rhyner, A., Weber, E., Dvorak, J., & Müntener, M. (2001). Active therapy for chronic low back pain: part 2. Effects on paraspinal muscle cross-sectional area, fiber type size, and distribution. Spine, 26(8), 909-919.


Katz, N., Borenstein, D. G., Birbara, C., Bramson, C., Nemeth, M. A., Smith, M. D., & Brown, M. T. (2011). Efficacy and safety of tanezumab in the treatment of chronic low back pain. PAIN®, 152(10), 2248-2258.


Keller, A., Hayden, J., Bombardier, C., & Van Tulder, M. (2007). Effect sizes of non-surgical treatments of non-specific low-back pain. European Spine Journal, 16(11), 1776-1788.


Keshari, K. R., Lotz, J. C., Link, T. M., Hu, S., Majumdar, S., & Kurhanewicz, J. (2008). Lactic acid and proteoglycans as metabolic markers for discogenic back pain. Spine, 33(3), 312-317.


Kidd, B. L., & Urban, L. A. (2001). Mechanisms of inflammatory pain. British journal of anaesthesia, 87(1), 3-11.


Kidd, B. (2012). Mechanisms of pain in osteoarthritis. HSS journal, 8(1), 26-28.


Kikuchi, S. (2008). New concept for backache: biopsychosocial pain syndrome. European Spine Journal, 17(4), 421-427.


Kim, D. H., Yoon, D. M., & Yoon, K. B. (2015). The effects of myofascial trigger point injections on nocturnal calf cramps. The Journal of the American Board of Family Medicine, 28(1), 21-27.


Kim, H., Kim, J., Loggia, M. L., Cahalan, C., Garcia, R. G., Vangel, M. G., & Napadow, V. (2015). Fibromyalgia is characterized by altered frontal and cerebellar structural covariance brain networks. NeuroImage: Clinical, 7, 667-677.


Kim, S. A., Oh, K. Y., Choi, W. H., & Kim, I. K. (2013). Ischemic compression after trigger point injection affect the treatment of myofascial trigger points. Annals of rehabilitation medicine, 37(4), 541-546.


Kimura, Y., Ge, H. Y., Zhang, Y., Kimura, M., Sumikura, H., & Arendt‐Nielsen, L. (2009). Evaluation of sympathetic vasoconstrictor response following nociceptive stimulation of latent myofascial trigger points in humans. Acta Physiologica, 196(4), 411-417.


Kinkade, S. (2007). Evaluation and treatment of acute low back pain. American Family Physician, 75(8).


Kiralp, M. Z., Ari, H., Karabekir, I., & Dursun, H. (2006). Comparison of low intensity laser therapy and trigger point injection in the management of myofascial pain syndrome. The Pain Clinic, 18(1), 63-66.


Koca, I., & Boyaci, A. (2014). A new insight into the management of myofascial pain syndrome. Gaziantep Med J, 20(2), 107-12.


Koes, B. W., Van Tulder, M. W., & Thomas, S. (2006). Diagnosis and treatment of low back pain. BMJ: British Medical Journal, 332(7555), 1430.


Krishnan, S. K., Benzon, H. T., Siddiqui, T., & Canlas, B. (2000). Pain on intramuscular injection of bupivacaine, ropivacaine, with and without dexamethasone. Regional anesthesia and pain medicine, 25(6), 615-619.


Kuan, L. C., Li, Y. T., Chen, F. M., Tseng, C. J., Wu, S. F., & Kuo, T. C. (2006). Efficacy of treating abdominal wall pain by local injection. Taiwanese Journal of Obstetrics and Gynecology, 45(3), 239-243.


Kuan, T. S., Hong, C. Z., Chen, J. T., Chen, S. M., & Chien, C. H. (2007). The spinal cord connections of the myofascial trigger spots. European Journal of Pain, 11(6), 624-634.


Kwekkeboom, K. L., Wanta, B., & Bumpus, M. (2008). Individual difference variables and the effects of progressive muscle relaxation and analgesic imagery interventions on cancer pain. Journal of pain and symptom management, 36(6), 604-615.


Kwekkeboom, K. L., Hau, H., Wanta, B., & Bumpus, M. (2008). Patients’ perceptions of the effectiveness of guided imagery and progressive muscle relaxation interventions used for cancer pain. Complementary therapies in clinical practice, 14(3), 185-194.


Lacomba, M. T., del Moral, O. M., Zazo, J. L. C., Gerwin, R. D., & Goñí, Á. Z. (2010). Incidence of myofascial pain syndrome in breast cancer surgery: a prospective study. The Clinical journal of pain, 26(4), 320-325.


Langford, C. F., Udvari Nagy, S., & Ghoniem, G. M. (2007). Levator ani trigger point injections: an underutilized treatment for chronic pelvic pain. Neurourology and urodynamics, 26(1), 59-62.


Las Peñas, D., Fernandez, C., Cuadrado, M. L., Gerwin, R. D., & Pareja, J. A. (2005). Referred Pain From the Trochlear Region in Tension‐Type Headache: A Myofascial Trigger Point From the Superior Oblique Muscle. Headache: The Journal of Head and Face Pain, 45(6), 731-737.


Latremoliere, A., & Woolf, C. J. (2009). Central sensitization: a generator of pain hypersensitivity by central neural plasticity. The Journal of Pain, 10(9), 895-926.


Lavelle, E. D., Lavelle, W., & Smith, H. S. (2007). Myofascial trigger points. Anesthesiology clinics, 25(4), 841-851.


Leng, T., Lin, J., Cottrell, J. E., & Xiong, Z. G. (2013). Subunit and frequency-dependent inhibition of acid sensing ion channels by local anesthetic tetracaine. Molecular pain, 9(1), 27.


Lin, J., Chu, X., Maysami, S., Li, M., Si, H., Cottrell, J. E., & Xiong, Z. (2011). Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesthesia and analgesia, 112(4), 977.


Lin, J. (2010). Effects of amide local anesthetics on acid sensing ion channels in cultured mouse cortical neurons. ASA Annual Meeting Abstract A284, San Diego.


Linnman, C., Appel, L., Fredrikson, M., Gordh, T., Söderlund, A., Långström, B., & Engler, H. (2011). Elevated [11C]-D-deprenyl uptake in chronic Whiplash Associated Disorder suggests persistent musculoskeletal inflammation. PLoS One, 6(4), e19182.


Lirk, P., Picardi, S., & Hollmann, M. W. (2014). Local anaesthetics: 10 essentials. European Journal of Anaesthesiology (EJA), 31(11), 575-585.


Ljunggren, A. E., Weber, H., Kogstad, O., Thom, E., & Kirkesola, G. (1997). Effect of Exercise on Sick Leave Due to Low Back Pain: A Randomized, Comparative, Long‐Term Study. Spine, 22(14), 1610-1616.


Lluch, E., Nijs, J., De Kooning, M., Van Dyck, D., Vanderstraeten, R., Struyf, F., & Roussel, N. A. (2015). Prevalence, incidence, localization, and pathophysiology of myofascial trigger points in patients with spinal pain: a systematic literature review. Journal of manipulative and physiological therapeutics, 38(8), 587-600.


Lucas, N., Macaskill, P., Irwig, L., Moran, R., & Bogduk, N. (2009). Reliability of physical examination for diagnosis of myofascial trigger points: a systematic review of the literature. The Clinical journal of pain, 25(1), 80-89.


Machado, L. A. C., Kamper, S. J., Herbert, R. D., Maher, C. G., & McAuley, J. H. (2008). Analgesic effects of treatments for non-specific low back pain: a meta-analysis of placebo-controlled randomized trials. Rheumatology, 48(5), 520-527.


Mamet, J., Baron, A., Lazdunski, M., & Voilley, N. (2002). Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. Journal of Neuroscience, 22(24), 10662-10670.


Mamet, J., Lazdunski, M., & Voilley, N. (2003). How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons. Journal of Biological Chemistry, 278(49), 48907-48913.


Mankodi, A., & Thornton, C. A. (2002). Myotonic syndromes. Current opinion in neurology, 15(5), 545-552.


Mannion, A. F., Käser, L., Weber, E., Rhyner, A., Dvorak, J., & Müntener, M. (2000). Influence of age and duration of symptoms on fibre type distribution and size of the back muscles in chronic low back pain patients. European Spine Journal, 9(4), 273-281.


Mannion, A. F., Taimela, S., Müntener, M., & Dvorak, J. (2001). Active therapy for chronic low back pain: part 1. Effects on back muscle activation, fatigability, and strength. Spine, 26(8), 897-908.


Mason, J. S., Tansey, K. A., & Westrick, R. B. (2014). Treatment of subacute posterior knee pain in an adolescent ballet dancer utilizing trigger point dry needling: a case report. International journal of sports physical therapy, 9(1), 116.


Mathew, N. T. (2006). Tension-type headache. Current neurology and neuroscience reports, 6(2), 100-105.


Matricon, J., Muller, E., Accarie, A., Meleine, M., Etienne, M., Voilley, N., ... & Gelot, A. (2013). Peripheral contribution of NGF and ASIC1a to colonic hypersensitivity in a rat model of irritable bowel syndrome. Neurogastroenterology & Motility, 25(11).


McNulty, W. H., Gevirtz, R. N., Hubbard, D. R., & Berkoff, G. M. (1994). Needle electromyographic evaluation of trigger point response to a psychological stressor. Psychophysiology, 31(3), 313-316.


McPartland, J. M., & Simons, D. G. (2006). Myofascial trigger points: translating molecular theory into manual therapy. Journal of Manual & Manipulative Therapy, 14(4), 232-239.


Meeus, M., Vervisch, S., De Clerck, L. S., Moorkens, G., Hans, G., & Nijs, J. (2012, February). Central sensitization in patients with rheumatoid arthritis: a systematic literature review. In Seminars in arthritis and rheumatism (Vol. 41, No. 4, pp. 556-567). WB Saunders.


Meireles, S. A., Antero, D. C., Kulczycki, M. M., & Skare, T. L. (2014). Prevalence of falls in fibromyalgia patients. Acta ortopedica brasileira, 22(3), 163-166.


Mellick, G. A., & Mellick, L. B. (2003). Regional head and face pain relief following lower cervical intramuscular anesthetic injection. Headache: The Journal of Head and Face Pain, 43(10), 1109-1111.


Meng, F., Ge, H. Y., Wang, Y. H., & Yue, S. W. (2015). A afferent fibers are involved in the pathology of central changes in the spinal dorsal horn associated with myofascial trigger spots in rats. Experimental brain research, 233(11), 3133-3143.


Mense, S. (1991). Considerations concerning the neurobiological basis of muscle pain. Canadian journal of physiology and pharmacology, 69(5), 610-616.


Mense, S. (2003). The pathogenesis of muscle pain. Current pain and headache reports, 7(6), 419-425.


Mense, S., Simons, D. G., Hoheisel, U., & Quenzer, B. (2003). Lesions of rat skeletal muscle after local block of acetylcholinesterase and neuromuscular stimulation. Journal of applied physiology, 94(6), 2494-2501.


Mense, S., Simons, D. G., Hoheisel, U., & Quenzer, B. (2003). Lesions of rat skeletal muscle after local block of acetylcholinesterase and neuromuscular stimulation. Journal of applied physiology, 94(6), 2494-2501.


Mense, S. (2008). Muscle pain: mechanisms and clinical significance. Deutsches Ärzteblatt International, 105(12), 214.


Mizumura, K. (2009). Peripheral mechanism of muscle pain: An update. Current Anaesthesia & Critical Care, 20(4), 183-187.


Mizumura, K., & Taguchi, T. (2016). Delayed onset muscle soreness: Involvement of neurotrophic factors. The Journal of Physiological Sciences, 66(1), 43-52.


Moldofsky, H. (2008). The significance, assessment, and management of nonrestorative sleep in fibromyalgia syndrome. CNS spectrums, 13(S5), 22-26.


Molliver, D. C., Immke, D. C., Fierro, L., Paré, M., Rice, F. L., & McCleskey, E. W. (2005). ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neurons. Molecular pain, 1(1), 35.


Moraska, A., & Chandler, C. (2008). Changes in clinical parameters in patients with tension-type headache following massage therapy: a pilot study. Journal of Manual & Manipulative Therapy, 16(2), 106-112.


Moraska, A. F., Hickner, R. C., Kohrt, W. M., & Brewer, A. (2013). Changes in blood flow and cellular metabolism at a myofascial trigger point with trigger point release (ischemic compression): a proof-of-principle pilot study. Archives of physical medicine and rehabilitation, 94(1), 196-200.


Murase, S., Terazawa, E., Queme, F., Ota, H., Matsuda, T., Hirate, K., & Mizumura, K. (2010). Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness). Journal of Neuroscience, 30(10), 3752-3761.


Murase, S., Terazawa, E., Hirate, K., Yamanaka, H., Kanda, H., Noguchi, K., & Mizumura, K. (2013). Upregulated glial cell line‐derived neurotrophic factor through cyclooxygenase‐2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats. The Journal of physiology, 591(12), 3035-3048.



Nair, B., & Taylor-Gjevre, R. (2010). A review of topical diclofenac use in musculoskeletal disease. Pharmaceuticals, 3(6), 1892-1908.


Nakamura, M., Nishiwaki, Y., Ushida, T., & Toyama, Y. (2011). Prevalence and characteristics of chronic musculoskeletal pain in Japan. Journal of orthopaedic science, 16(4), 424-432.


Nadler, S. F. (2004). Nonpharmacologic management of pain. Journal of the American Osteopathic Association, 104(11 supplement), 6S.


Nguyen, B. M. (2013). Myofascial trigger point, falls in the elderly, idiopathic knee pain and osteoarthritis: an alternative concept. Medical hypotheses, 80(6), 806-809.


Niddam, D. M., Chan, R. C., Lee, S. H., Yeh, T. C., & Hsieh, J. C. (2007). Central modulation of pain evoked from myofascial trigger point. The Clinical journal of pain, 23(5), 440-448.


Niddam, D. M., Chan, R. C., Lee, S. H., Yeh, T. C., & Hsieh, J. C. (2008). Central representation of hyperalgesia from myofascial trigger point. Neuroimage, 39(3), 1299-1306.


Niraj, G., Collett, B. J., & Bone, M. (2011). Ultrasound-guided trigger point injection: first description of changes visible on ultrasound scanning in the muscle containing the trigger point. British journal of anaesthesia, 107(3), 474-475.


Ota, H., Katanosaka, K., Murase, S., Kashio, M., Tominaga, M., & Mizumura, K. (2013). TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness. PLoS One, 8(6), e65751.


Pal, U. S., Kumar, L., Mehta, G., Singh, N., Singh, G., Singh, M., & Yadav, H. K. (2014). Trends in management of myofacial pain. National journal of maxillofacial surgery, 5(2), 109.


Park, H. J., & Moon, D. E. (2010). Pharmacologic management of chronic pain. The Korean journal of pain, 23(2), 99-108.


Paukert, M., Babini, E., Pusch, M., & Gründer, S. (2004). Identification of the Ca2+ Blocking Site of Acid-sensing Ion Channel (ASIC) 1. The Journal of general physiology, 124(4), 383-394.


Peng, P. W., & Castano, E. D. (2005). Survey of chronic pain practice by anesthesiologists in Canada. Canadian Journal of Anesthesia, 52(4), 383.


Podolecki, T., Podolecki, A., & Hrycek, A. (2009). Fibromyalgia: pathogenetic, diagnostic and therapeutic concerns. Pol Arch Med Wewn, 119(3), 157-61.


Prateepavanich, P., Kupniratsaikul, V., & Charoensak, T. (1999). The relationship between myofascial trigger points of gastrocnemius muscle and nocturnal calf cramps. Journal of the Medical Association of Thailand= Chotmaihet thangphaet, 82(5), 451-459.


Pusch, M. (2002). Myotonia caused by mutations in the muscle chloride channel gene CLCN1. Human mutation, 19(4), 423-434.


Quintner, J. L., Bove, G. M., & Cohen, M. L. (2014). A critical evaluation of the trigger point phenomenon. Rheumatology, 54(3), 392-399.


Rai, S., Ranjan, V., Misra, D., & Panjwani, S. (2016). Management of myofascial pain by therapeutic ultrasound and transcutaneous electrical nerve stimulation: A comparative study. European journal of dentistry, 10(1), 46.


Raphael, K. G., Janal, M. N., Ananthan, S., Cook, D. B., & Staud, R. (2009). Temporal summation of heat pain in temporomandibular disorder patients. Journal of orofacial pain, 23(1), 54.


Resteghini, P. (2006). Myofascial Trigger Points: Pathophysiology and Treatment with Dry Needling. Journal of Orthopaedic Medicine, 28(2), 60-68.


Rosendal, L., Larsson, B., Kristiansen, J., Peolsson, M., Søgaard, K., Kjær, M., & Gerdle, B. (2004). Increase in muscle nociceptive substances and anaerobic metabolism in patients with trapezius myalgia: microdialysis in rest and during exercise. Pain, 112(3), 324-334.


Roth, J. K., Roth, R. S., Weintraub, J. R., & Simons, D. G. (2007). Cervicogenic headache caused by myofascial trigger points in the sternocleidomastoid: a case report. Cephalalgia, 27(4), 375-380.


Saxena, A., Chansoria, M., Tomar, G., & Kumar, A. (2015). Myofascial pain syndrome: an overview. Journal of pain & palliative care pharmacotherapy, 29(1), 16-21.


Scott, N., Guo, B., Barton, P. M., & Gerwin, R. D. (2009). Trigger Point Injections for Chronic Non‐Malignant Musculoskeletal Pain: A Systematic Review. Pain Medicine, 10(1), 54-69.


Schnider, P., Moraru, E., Vigl, M., Wöber, C., Földy, D., Maly, J., & Auff, E. (2002). Physical therapy and adjunctive botulinum toxin type A in the treatment of cervical headache: a double-blind, randomised, placebo-controlled study. The journal of headache and pain, 3(2), 93-99.


Seol, S. J., Cho, H., Yoon, D. H., & Jang, S. H. (2014). Appropriate depth of needle insertion during rhomboid major trigger point block. Annals of rehabilitation medicine, 38(1), 72-76.


Sergienko, S., & Kalichman, L. (2015). Myofascial origin of shoulder pain: a literature review. Journal of bodywork and movement therapies, 19(1), 91-101.


Schaible, H. G. (2012). Mechanisms of chronic pain in osteoarthritis. Current rheumatology reports, 14(6), 549-556.


Scott, N., Guo, B., Barton, P. M., & Gerwin, R. D. (2009). Trigger Point Injections for Chronic Non‐Malignant Musculoskeletal Pain: A Systematic Review. Pain Medicine, 10(1), 54-69.


Shah, J. P., Phillips, T. M., Danoff, J. V., & Gerber, L. H. (2005). An in vivo microanalytical technique for measuring the local biochemical milieu of human skeletal muscle. Journal of applied physiology, 99(5), 1977-1984.
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Shah, J. P., Danoff, J. V., Desai, M. J., Parikh, S., Nakamura, L. Y., Phillips, T. M., & Gerber, L. H. (2008). Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Archives of physical medicine and rehabilitation, 89(1), 16-23.


Shah, J. P., & Gilliams, E. A. (2008). Uncovering the biochemical milieu of myofascial trigger points using in vivo microdialysis: an application of muscle pain concepts to myofascial pain syndrome. Journal of bodywork and movement therapies, 12(4), 371-384.


Shankar, H., & Reddy, S. (2012). Two-and three-dimensional ultrasound imaging to facilitate detection and targeting of taut bands in myofascial pain syndrome. Pain Medicine, 13(7), 971-975.


Shen, F. H., Samartzis, D., & Andersson, G. B. (2006). Nonsurgical management of acute and chronic low back pain. Journal of the American academy of orthopaedic surgeons, 14(8), 477-487.


Sikdar, S., Shah, J. P., Gebreab, T., Yen, R. H., Gilliams, E., Danoff, J., & Gerber, L. H. (2009). Novel applications of ultrasound technology to visualize and characterize myofascial trigger points and surrounding soft tissue. Archives of physical medicine and rehabilitation, 90(11), 1829-1838.


Sikdar, S., Ortiz, R., Gebreab, T., Gerber, L. H., & Shah, J. P. (2010, August). Understanding the vascular environment of myofascial trigger points using ultrasonic imaging and computational modeling. In Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE (pp. 5302-5305). IEEE.


Simons, D. G. (2003). Cardiology and myofascial trigger points: Janet G. Travell's contribution. Texas heart institute journal, 30(1), 3.


Simons, D. G. (2004). Review of enigmatic MTrPs as a common cause of enigmatic musculoskeletal pain and dysfunction. Journal of electromyography and kinesiology, 14(1), 95-107.


Simons, D. G. (2008). New views of myofascial trigger points: etiology and diagnosis. Archives of physical medicine and rehabilitation, 89(1), 157-159.


Sluka, K. A., Kalra, A., & Moore, S. A. (2001). Unilateral intramuscular injections of acidic saline produce a bilateral, long‐lasting hyperalgesia. Muscle & nerve, 24(1), 37-46.


Sluka, K. A., Price, M. P., Breese, N. M., Stucky, C. L., Wemmie, J. A., & Welsh, M. J. (2003). Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1. Pain, 106(3), 229-239.


Smart, K. M., Blake, C., Staines, A., & Doody, C. (2011). The Discriminative validity of “nociceptive,”“peripheral neuropathic,” and “central sensitization” as mechanisms-based classifications of musculoskeletal pain. The Clinical journal of pain, 27(8), 655-663.


Smart, K. M., Blake, C., Staines, A., Thacker, M., & Doody, C. (2012). Mechanisms-based classifications of musculoskeletal pain: part 1 of 3: symptoms and signs of central sensitisation in patients with low back (±leg) pain. Manual therapy, 17(4), 336-344.


Smart, K. M., Blake, C., Staines, A., Thacker, M., & Doody, C. (2012). Mechanisms-based classifications of musculoskeletal pain: part 2 of 3: symptoms and signs of peripheral neuropathic pain in patients with low back (±leg) pain. Manual therapy, 17(4), 345-351.


Smart, K. M., Blake, C., Staines, A., Thacker, M., & Doody, C. (2012). Mechanisms-based classifications of musculoskeletal pain: part 3 of 3: symptoms and signs of nociceptive pain in patients with low back (±leg) pain. Manual therapy, 17(4), 352-357.


Soares, A., Andriolo, R. B., Atallah, Á. N., & Da Silva, E. M. (2012). Botulinum toxin for myofascial pain syndromes in adults. Cochrane Database Syst Rev, 4.


Staud, R. (2006). Biology and therapy of fibromyalgia: pain in fibromyalgia syndrome. Arthritis research & therapy, 8(3), 208.


Staud, R. (2007). Future perspectives: pathogenesis of chronic muscle pain. Best Practice & Research Clinical Rheumatology, 21(3), 581-596.


Staud, R. (2010). Is it all central sensitization? Role of peripheral tissue nociception in chronic musculoskeletal pain. Current rheumatology reports, 12(6), 448-454.


Staud, R. (2011). Peripheral pain mechanisms in chronic widespread pain. Best Practice & Research Clinical Rheumatology, 25(2), 155-164.


Staud, R., Weyl, E. E., Bartley, E., Price, D. D., & Robinson, M. E. (2014). Analgesic and anti‐hyperalgesic effects of muscle injections with lidocaine or saline in patients with fibromyalgia syndrome. European Journal of Pain, 18(6), 803-812.


Strazar, A. R., Leynes, P. G., & Lalonde, D. H. (2013). Minimizing the pain of local anesthesia injection. Plastic and reconstructive surgery, 132(3), 675-684.


Strong, J. A., Xie, W., Bataille, F. J., & Zhang, J. M. (2013). Preclinical studies of low back pain. Molecular pain, 9(1), 17.


Suka, M., & Yoshida, K. (2009). The national burden of musculoskeletal pain in Japan: Projections to the year 2055. The Clinical journal of pain, 25(4), 313-319.


Sultan, A., Gaskell, H., Derry, S., & Moore, R. A. (2008). Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials. BMC neurology, 8(1), 29.


Sun, A., Yeo, H. G., Kim, T. U., Hyun, J. K., & Kim, J. Y. (2014). Radiologic assessment of forward head posture and its relation to myofascial pain syndrome. Annals of rehabilitation medicine, 38(6), 821-826.


Taguchi, T., Matsuda, T., Tamura, R., Sato, J., & Mizumura, K. (2005). Muscular mechanical hyperalgesia revealed by behavioural pain test and c‐Fos expression in the spinal dorsal horn after eccentric contraction in rats. The Journal of physiology, 564(1), 259-268.


Taguchi, T., Sato, J., & Mizumura, K. (2005). Augmented mechanical response of muscle thin-fiber sensory receptors recorded from rat muscle–nerve preparations in vitro after eccentric contraction. Journal of Neurophysiology, 94(4), 2822-2831.


Taguchi, T., Hoheisel, U., & Mense, S. (2008). Dorsal horn neurons having input from low back structures in rats. Pain, 138(1), 119-129.


Taguchi, T., Yasui, M., Kubo, A., Abe, M., Kiyama, H., Yamanaka, A., & Mizumura, K. (2013). Nociception originating from the crural fascia in rats. PAIN®, 154(7), 1103-1114.


Tesarz, J., Hoheisel, U., Wiedenhöfer, B., & Mense, S. (2011). Sensory innervation of the thoracolumbar fascia in rats and humans. Neuroscience, 194, 302-308.


Thomas, E., Silman, A. J., Croft, P. R., Papageorgiou, A. C., Jayson, M. I., & Macfarlane, G. J. (1999). Predicting who develops chronic low back pain in primary care: a prospective study. Bmj, 318(7199), 1662-1667.


Toumi, H., & Best, T. M. (2003). The inflammatory response: friend or enemy for muscle injury?. British journal of sports medicine, 37(4), 284-286.


Travell, J. (1960). Temporomandibular joint pain referred from muscles of the head and neck. The Journal of Prosthetic Dentistry, 10(4), 745-763.


Tsen, L. C., & Camann, W. R. (1997). Trigger point injections for myofascial pain during epidural analgesia for labor. Regional Anesthesia and Pain Medicine, 22(5), 466-468.


Van Middelkoop, M., Rubinstein, S. M., Kuijpers, T., Verhagen, A. P., Ostelo, R., Koes, B. W., & van Tulder, M. W. (2011). A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. European Spine Journal, 20(1), 19-39.


Van Tulder, M. W., Scholten, R. J., Koes, B. W., & Deyo, R. A. (2000). Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev, 2.


Vázquez Delgado, E., Cascos-Romero, J., & Gay Escoda, C. (2009). Myofascial pain syndrome associated with trigger points: a literature review.(I): Epidemiology, clinical treatment and etiopathogeny. Medicina Oral, Patología Oral y Cirugia Bucal, 2009, vol. 14, num. 10, p. 494-498.


Vázquez Delgado, E., Cascos-Romero, J., & Gay Escoda, C. (2010). Myofascial pain associated to trigger points: a literature review. Part 2: differential diagnosis and treatment. Medicina Oral, Patología Oral y Cirugia Bucal, 2010, vol. 15, num. 4, p. 639-643.


Voilley, N., de Weille, J., Mamet, J., & Lazdunski, M. (2001). Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. Journal of Neuroscience, 21(20), 8026-8033.


Voilley, N. (2004). Acid-sensing ion channels (ASICs): New targets for the analgesic effects of Non-Steroid Anti-Inflammatory Drugs (NSAIDs). Current Drug Targets-Inflammation & Allergy, 3(1), 71-79.


Vivian, D., & Verrills, P. (2004). Interventions in chronic low back pain. Australian family physician, 33(6), 421.


Waldmann, G., Schauer, M., Woldag, H., & Hummelsheim, H. (2010). Choosing the optimal trigger point for analysis of movements after stroke based on magnetoencephalographic recordings. Stroke research and treatment, 2010.


Wheeler, A. H., Goolkasian, P., & Gretz, S. S. (2001). Botulinum toxin A for the treatment of chronic neck pain. Pain, 94(3), 255-260.


Wilk, V. (2004). Acute low back pain: assessment and management. Australian family physician, 33(6), 403.


Wong, C. S., & Wong, S. H. (2012). A new look at trigger point injections. Anesthesiology research and practice, 2012.


Woolf, C. J. (2011). Central sensitization: implications for the diagnosis and treatment of pain. Pain, 152(3), S2-S15.


Xiaoqiang, Z., Shusheng, T., & Qiangmin, H. (2014). Understanding of myofascial trigger points. Chinese medical journal, 127(24), 4271-4277.


Yakhno, N., Guekht, A., Skoromets, A., Spirin, N., Strachunskaya, E., Ternavsky, A., & Moller, P. L. (2006). Analgesic efficacy and safety of lornoxicam quick-release formulation compared with diclofenac potassium. Clinical drug investigation, 26(5), 267-277.


Yentür, E. A., Okçu, G., & Yegül, I. B. (2003). The role of trigger point therapy in knee osteoarthritis. The pain clinic, 15(4), 385-390.


Yap, E. (2007). Myofascial pain-an overview. Annals-Academy of Medicine Singapore, 36(1), 43.


Yoshida, K., Sekiguchi, M., Otani, K., Mashiko, H., Shiota, H., Wakita, T., & Konno, S. I. (2011). A validation study of the Brief Scale for Psychiatric problems in Orthopaedic Patients (BS-POP) for patients with chronic low back pain (verification of reliability, validity, and reproducibility). Journal of Orthopaedic Science, 16(1), 7-13.


Zaralidou, A. T., Amaniti, E. N., Maidatsi, P. G., Gorgias, N. K., & Vasilakos, D. F. (2007). Comparison between newer local anesthetics for myofascial pain syndrome management. Methods and findings in experimental and clinical pharmacology, 29(5), 353-358.


Zimmermann, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16(2), 109-110.


Zha, X. M. (2013). Acid-sensing ion channels: trafficking and synaptic function. Molecular brain, 6(1), 1.


Zhang, Y., Ge, H. Y., Yue, S. W., Kimura, Y., & Arendt-Nielsen, L. (2009). Attenuated skin blood flow response to nociceptive stimulation of latent myofascial trigger points. Archives of physical medicine and rehabilitation, 90(2), 325-332.

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